GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6797178 | 1 | rs6797178 | chr3:137253713 | NCK1 | chr3:136581073-136667967:+ | 0.13 | 3.49 | 0.000519 | Glucocorticoid-induced osteonecrosis |
| THCA | cis | rs73201462 | 1 | rs6797834 | chr3:127856400 | EEFSEC | chr3:127872313-128127488:+ | -0.26 | -4.47 | 9.77E-6 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs7692995 | 1 | rs67978911 | chr4:17991423 | DCAF16 | chr4:17802280-17812381:- | -0.2 | -4.39 | 1.41E-5 | Height |
| THCA | cis | rs67981189 | 1 | rs67981189 | chr14:71472226 | PCNX | chr14:71374122-71582099:+ | -0.2 | -6.84 | 2.45E-11 | Schizophrenia |
| THCA | cis | rs73201462 | 1 | rs6798749 | chr3:128056897 | EEFSEC | chr3:127872313-128127488:+ | 0.21 | 3.55 | 0.000422 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs11825709 | 1 | rs67988338 | chr11:93704731 | HEPHL1 | chr11:93754378-93847374:+ | 0.48 | 3.87 | 0.000126 | Obesity-related traits |
| THCA | cis | rs7116495 | 1 | rs679926 | chr11:71769936 | FAM86C | chr11:71498557-71512276:+ | -0.33 | -4.1 | 4.89E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs6684514 | 1 | rs6800 | chr1:156262653 | BGLAP | chr1:156182784-156213112:+ | 0.23 | 5.32 | 1.63E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THCA | cis | rs6684514 | 1 | rs6800 | chr1:156262653 | C1orf85 | chr1:156259882-156265449:- | -0.17 | -3.99 | 7.72E-5 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THCA | cis | rs6684514 | 1 | rs6800 | chr1:156262653 | CCT3 | chr1:156278752-156308195:- | -0.32 | -6.95 | 1.24E-11 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THCA | cis | rs6800225 | 1 | rs6800225 | chr3:127862178 | EEFSEC | chr3:127872313-128127488:+ | -0.26 | -4.47 | 9.77E-6 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs4332428 | 1 | rs68005215 | chr10:4977435 | AKR1C2 | chr10:4964715-5060207:- | 0.32 | 4.2 | 3.25E-5 | Height |
| THCA | cis | rs7631605 | 1 | rs6800554 | chr3:37143879 | EPM2AIP1 | chr3:37027358-37034795:- | -0.13 | -3.85 | 0.000132 | Cerebrospinal P-tau181p levels |
| THCA | cis | rs7631605 | 1 | rs6800554 | chr3:37143879 | LRRFIP2 | chr3:37094117-37217851:- | -0.5 | -13.54 | 1.44E-35 | Cerebrospinal P-tau181p levels |
| THCA | cis | rs6805251 | 1 | rs6800622 | chr3:119580678 | GSK3B | chr3:119540804-119813264:- | -0.14 | -4.93 | 1.11E-6 | HDL cholesterol |